Endothelin Essay -- Health

Cardiovascular unsoundness is one of the leading deaths in the United States. pulmonary hypertension disease one type of cardiovascular disease that is collectable to the narrowing of the arteries within the lungs. When the arteries are narrowed the right side of the flavour is unable to pump blood through the lungs, pressure begin to mannikin up and not enough oxygen is being picked up, on that pointfore causing pulmonary hypertension. If there are damages to the endothelium, it can aim this disease because it can produce more endothelin-1, which is one of the isomer of Endothelin that influence as a vasoconstrictor.IntroductionIt is important to have treatment on tap(predicate) to patients who suffer from cardiovascular diseases. Since it is one of the leading causes of deaths in the United States, improving treatments will drop a line many lives. Although sum total disease occur more in enceinte patients, there are possible chances in which infants are affected by a dise ase known as the congenital heart disease. In order to have treatment for patient with heart disease, we need to wait at the molecular level. Patients were examined and documents showed that endothelial injury may be the cause for pulmonary hypertension and other vascular diseases.PresentationEndothelin is a 21 amino acid polypeptide that has 3 different isoforms which are endothelin-1(ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). ET-1 is located primarily in the endothelial cell but is a regulator of smooth-spoken muscle, heart, and kidney. ET-2 differs from ET-1 by 2 amino acids and is also found in the heart and kidney. ET-3 differs from ET-1 by 6 amino acids and is produced in the central nervous placement like ET-1and in gastrointestinal (1). With researches, ET-1 is more focused on in cardiovascu... ...With different experimental data on animals and documents of patient with cardiovascular diseases, there no exact conclusion made on which receptors antagonist may c ure the disease. Trials are needed to determine whether ETA/B blockage or just ETA blockade is better in the treatment of hypertension or any other vascular disease. Although both decrease vasoconstriction, potential anti-endothelin therapy is available to patients.Works Cited1. Agapotiv, Alexei & Haynes, William. Role of Endothelin in Cardiovascular Disease. Journal of Renin0Angiotensin-Aldosterone System, 3.1 (2002) 2-10. .2. Bohm, Felix & Pernow, John. The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Cardiovascular Research, 76.1 (2007) 8-18..